I've been playing quite a bit of slide. And have chronic problem with the small E string sounding weaker than the rest. Seems to be consistent over several guitars, and even when being very careful about technique-- not bottoming out; regardless of the amount of pressure/contact.
So, I started thinking about setting up a guitar for slide. I've been playing my old (sorta) tele. The Musicians Friend special with set neck, thin body, DiMarzio humbuckers with coil tap switch.
To make it a better slide guitar, I raised the action a bit, especially on the high E side. And put on a set of 11-50 (DR) on. I've been using a 10-46 set for a long time. Jury is still out on whether this helped/solve the weak E string issue.
But I am surprised to find very little difference in bending and vibrato difficulty. Checked and adjusted intonation. Didn't seem to bow the neck noticeably, so left the truss rod alone for now. Nut slots may not be big enough, but leaving them alone for now, as this is just an experiment, so far.
(Overthinking this, but...) I guess the difference, as a percentage, is less going from 10 to 11; than 9 to 10. For me the difference between 9 and 10 was substantial. But from 10 to 11, is almost not noticeable from a playing standpoint.